Topics » Disease » The Quality of Your Plant-Based Diet Matters for Heart Disease Risk
T. Colin Campbell Center for Nutrition Studies
The Quality of Your Plant-Based Diet Matters for Heart Disease Risk

When it comes to heart disease risk, the quality of a plant-based diet matters, according to new research published in the Journal of the American College of Cardiology.

Diets composed of more healthful plant-based foods were tied to a lower coronary heart disease risk and less healthful plant-based diets were associated with a higher coronary heart disease risk.[1]

Plant-based diets have been tied to a lower risk of coronary heart disease, however, most of the previous studies looking at the benefits of a plant-based diet used the term “vegetarian” describing several dietary patterns that exclude all or some animal products. Likewise, previous studies typically treated all plant foods equally including refined grains and sugar-sweetened beverages.

Ambika Satija, ScD from the Department of Nutrition at the Harvard T.H. Chan School of Public Health in Boston and colleagues sought to better understand the association between different degrees of plant-based diet quality on coronary heart disease incidence.

The investigators created 3 graded plant-based diet indices. The first was the overall plant-based diet index (PDI) which included all plant foods with reduction of animal products. The second was the healthful plant-based diet index (hPDI) which focused on foods such as whole-grains, vegetables, fruits, nuts, and legumes. Also included was an unhealthful plant-based diet index (uPDI) which included less healthy plant-based foods such as fruit juices, refined grains, potatoes/fries, and sweetened foods and drinks.

The study population included participants from the Nurses’ Health Study (NHS), the Nurses’ Health Study 2, and the Health Professional Follow-up study (HPFS). These studies excluded participants with baseline coronary heart disease, stroke, and non-melanoma skin cancers. The plant-based diet indices were then applied to data obtained from diet frequency questionnaires the participants completed every 2 to 4 years. For this current study, data was analyzed on 73,710 women in the NSH, 92,329 women from the NSH2, and 43,259 men from the HPFS.

After follow up, 8,631 participants developed coronary heart disease. The investigators found a higher adherence to the overall plant-based diet index was slightly associated with a reduced risk of coronary heart disease (HR 0.92, 95% CI: 0.83-1.01 P=0.003 for trend). However, the risk of heart disease was significantly lower for the more healthful plant-based diet index (HR 0.75, 95% CI: 0.68-0.83, P <0.001 for trend). Interestingly, the unhealthful plant-based diet index was associated with an increased risk for heart disease (HR 1.32, 95% CI: 1.20-1.46, P<0.001 for trend).

The authors offered several possible mechanisms for the association between a more healthful plant-based diet and reduced heart disease. The more healthful plant-based diets include higher intake of fiber, antioxidants, and micronutrients and lower intake of saturated fat and heme iron. Therefore, may lead to weight loss, better blood sugar and insulin levels, reduced blood pressure and lipids, improvements in vascular health, lower inflammation, and improvements in the diet-gut microbiome leading to lower trimethylamine N-oxide (TMAO), according to the paper.[1]

“When we examined the associations of the three food categories with heart disease risk, we found that healthy plant foods were associated with lower risk, whereas less healthy plant foods and animal foods were associated with higher risk. It’s apparent that there is a wide variation in the nutritional quality of plant foods, making it crucial to take into consideration the quality of foods in a plant-based diet,” Satija said in a press statement.[2]

In an accompanying editorial, Kim Allan Williams Sr., MD of the Division of Cardiology at Rush University Medical Center in Chicago highlights that this study may lead to a “risk-based” approached to prescribing plant-based diets. For instance, patients with a history of cardiac events or those with a high risk for cardiovascular disease would have a stronger recommendation for the more strict plant-based diet (hPDI).

Further, Dr. Williams addresses the “all-or-none” mindset that may lead to patients feeling that reaching dietary or exercise goals are unattainable. He notes, “Just as physical activity is a continuum, perhaps an emphasis on starting with smaller dietary tweaks rather than major changes would be more encouraging and sustainable for those finding it difficult to make a complete and precipitous change in dietary habits.” A simple approach was recently coined by Michael Pollan, Eat food. Not too much. Mostly plants.[3]

Limitations of the study included its observational nature and possible measurement errors in dietary assessments.

The study was supported by grants from the National Institutes of Health. Investigator disclosures included Dr. Chiuve’s employment by AbbVie, Dr. Rimm received grants from the DOA and Blueberry Highbush Counsel, and Dr. Hu received support from the California Walnut Commission and Metagenics.


  1. Satija A, Bhupathiraju SN, Spiegelman D, et al. Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in U.S. Adults. J Am Coll Cardiol. 2017;70(4):411-422.
  2. Not All Plant-Based Diets Are Created Equal. American College of Cardiology Press Releases. 17, July 2017,
  3. Williams KA, Patel H. Healthy Plant-Based Diet: What Does it Really Mean?. J Am Coll Cardiol. 2017;70(4):423-425.

Copyright 2024 Center for Nutrition Studies. All rights reserved.

Program Overview

  • 23,000+ students
  • 100% online, learn at your own pace
  • No prerequisites
  • Continuing education credits