Can Nutrition Help Prevent Common Cold & Flu Viruses?
Most respiratory tract infections (RTIs), including the common cold and flu (influenza) are caused by viruses. There are around 200 or more types and sub-types of virus that contribute. Further, viral DNA changes frequently. This makes preventing and treating RTIs quite difficult and helps explain why we tend to get many RTIs throughout our lives. Although we tend to think of a few days off work/school with a warm blanket, RTIs can be very serious, especially in those with a weakened immune system such as the elderly or those with certain medical conditions.
There is some evidence that low-fat, high-carbohydrate diets enhance the immune system.
RTIs are usually spread through contact with others who are infected, for example from exposure to coughs, sneezes, and even breath. With this in mind, RTIs spread rapidly when people are in confined spaces: think of schools, large office blocks, public transportation, etc. Contaminated surfaces such as hands are major sources of transmission. For example, a person touching their nose, and then shaking your hand or touching a surface that you then touch with your own hand.
Therefore, one of the most important aspects to preventing RTIs is ensuring good hygiene practices, particularly regular hand washing. Of course, we don’t all wash our hands repeatedly everyday. Even if we practice good personal hygiene, it is unlikely that every individual we come into close proximity with does! This makes it almost impossible to avoid germs from others. Fortunately, there are other things that can influence our immune system—including a healthy diet—all of which can decrease RTI risk even when germs are all around us.
7 Factors Associated With Decreased Immune Function
- Excess alcohol
- Poor sleep – In one study of over 22,000 Americans, a short sleep duration was associated with increased RTI risk of up to 82%. In another study, healthy volunteers were exposed to ‘nasal drops containing a rhinovirus’ (in other words mucous infected with the cold virus). Those who regularly sleep less than 7 hours per night were 200% more likely to develop a cold than those with 8 hours of sleep or more.
- Intense exercise
- Obesity increases both the risk and severity of RTI. Being overweight is associated with decreased immune response to influenza viru  and decreased response to flu vaccines.
- Excess dietary fat
- Psychological stress has been shown to weaken the system. Further, high levels of stress have been associated with decreased response to flu vaccination and increased risk of RTI. On the other hand, there is some evidence that stress-management is associated with increased response to flu vaccination.
7 Factors Associated With Superior Immune Function
- Low-fat, high-carb diets – There is some evidence that high fat diets are associated with decrease immune responses while low-fat, high-carbohydrate diets enhance the immune system.
- Micronutrients, including vitamins (e.g. vitamin C)
- Vitamin D was traditionally thought to be only important for bone health. However, recent evidence suggests that vitamin D has many important roles in the immune system. In fact, vitamin D seems to have important roles in every type of immune cell. A large review published in the prestigious journal British Medical Journal reported on all studies which used vitamin D supplements to prevent RTI. This impressive review included 25 studies of over 11,000 individuals. Vitamin D supplementation decreased RTI by 12%. For more detailed information regarding vitamin D and how to get enough, see my article on vitamin D facts.
- Minerals and trace elements (e.g. zinc, iron and selenium). Zinc is found in whole grains (particularly wheat-germ and wheat-bran) as well as various seeds and nuts, celery, mustard and legumes. Iron is found in legumes, tofu, green leafy and vegetables. Selenium can be found in whole-grains and mushrooms, but the greatest quantities are found in nuts, particularly Brazil nuts. It can be more difficult to absorb zinc and iron from a whole food, plant-based (WFPB) diet, and therefore it is important to ensure an adequate intake of the foods listed above. Further, try to combine these foods with sources of vitamin C to increase absorption. For example, legumes with bell pepper or nuts with an orange.
- Phytonutrients. “Phyto” means plant, so phytonutrients are non-essential but highly beneficial nutrients found only in plant foods. There is evidence that phytonutrients have antiviral properties and can help decrease RTI risk.
- Fiber – In the past, dietary fiber was thought to be indigestible and only beneficial in promoting gut health. We now know that fiber can be at least partially digested by bacteria living in our guts. When we eat foods containing fiber, these bacteria digest the fiber, and they produce by-products (e.g. short chain fatty acids) that are known to have beneficial effects on the immune system. Similar to phytonutrients, fiber is only found in whole plant foods such as fruit, vegetables, legumes, and whole grains.
- Moderate and regular exercise are important for overall health, including the immune system. For example, moderate exercise significantly improved antibody response to influenza vaccine.[18-20] However, be careful not to overdo it. Too much exercise can actually have the opposite effect.
Nutrition and Immune Function
There is limited evidence regarding nutrition and RTIs specifically, but some of the available evidence is very interesting.
A study from the late 1980s reported that the total number of white blood cells did not differ between meat eaters and those following a plant-based diet. However, one very important type of immune cell (called natural killer cells) were more active in the plant-based group. This suggests increased protection against not only RTI, but also cancer. In fact, an earlier study from Australia reported that RTIs were lower in those eating a plant-based diet compared to meat eaters at every age group. Interestingly, RTI rates were higher in vegetarians than in those eating a high fruit and vegetable diet. This study suggests that eating a plant-based diet can be beneficial, but actually consuming fruits and vegetables as opposed to other plant-based foods may be optimal.
A 2010 study including over 1,000 pregnant women in Boston reported that those eating the most fruit and vegetables had 39% reduced RTI risk.
An interesting German study was published in the British Journal of Nutrition in 1999. The researchers recruited non-smoking, adult men and asked them not to eat many fruits or vegetables for two weeks. These men were then asked to consume tomato juice every day for 2 weeks, then carrot juice daily for another two weeks and finally dried spinach daily for 2 weeks. Immune function was decreased during the first two weeks of the study (i.e. low fruit & vegetable). The other treatments, particularly tomato juice increased function significantly.
Certain sections of the population are at greater risk of severe RTI including infants, those with immune conditions, and the elderly. A fascinating study was completed by researchers in Northern Ireland and published in the nutrition journal, American Journal of Clinical Nutrition. This study included a group of adults aged 65 years and older who had a low intake of fruit and vegetables (2 servings per day). These subjects were randomised to continue their normal diet or increase fruit and vegetable intake to 5 servings per day. After 12 weeks, vaccinations were administered. The antibody response in the 5 servings group was significantly higher than in the 2 servings group, indicating greater immune response in those eating more fruits and vegetables.
Fruits and vegetables even seem to decrease infection risk in pregnancy. A 2010 study including over 1,000 pregnant women in Boston reported that those eating the most fruit and vegetables had 39% reduced RTI risk.
Nutrition and Influenza
A large 2010 US study reported that a 5% increase in obesity or physical inactivity would lead to a 6% to 7% increase in flu hospitalizations. However, low fruit and veg intake would lead to an 8% increase in flu hospitalizations.
So maybe an apple a day does keep the doctor away…well, a study published in the New York State Dental Journal reported that asking subjects to eat a single apple per day decreased RTIs by 16%!
4 Key Takeaways
A healthy immune system minimizes RTI risk and helps you recover quicker.
A WFPB diet will contain high levels of nutrients important for the immune system while decreasing undesirable nutrients.
Non-dietary practices are vitally important for the immune system (e.g. good sleep practices).
Combining these strategies will help achieve and maintain a healthy immune system. In turn, this will reduce RTI risk.
- Szabo G. Consequences of alcohol consumption on host defence. Alcohol Alcohol. 1999 Nov-Dec;34(6):830-41.
- Diaz LE. Influence of alcohol consumption on immunological status: a review. Eur J Clin Nutr. 2002 Aug;56 Suppl 3:S50-3.
- Prather AA, Leung CW. Association of Insufficient Sleep With Respiratory Infection Among Adults in the United States. JAMA Intern Med. 2016 Jun 1;176(6):850-2.
- Cohen S, Doyle WJ, Alper CM, Janicki-Deverts D, Turner RB. Sleep habits and susceptibility to the common cold. Arch Intern Med 2009;169:62-7.
- Paich HA, Sheridan PA, Handy J, Karlsson EA, Schultz-Cherry S, Hudgens MG, Noah TL, Weir SS, Beck MA. Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus. Obesity (Silver Spring). 2013 Nov;21(11):2377-86. doi: 10.1002/oby.20383. Epub 2013 May 30
- Sheridan PA, Paich HA, Handy J, et al. Obesity is associated with impaired immune response to influenza vaccination in humans. Int J Obes (Lond) 2012;36:1072-7.
- Barone J, Hebert JR, Reddy MM. Dietary fat and natural-killer-cell activity. Am J Clin Nutr. 1989 Oct;50(4):861-7.
- Yaqoob P. Monounsaturated fats and immune function. Proc Nutr Soc. 1998 Nov;57(4):511-20.
- Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004 Jul;130(4):601-30.
- Moynihan JA, Larson MR, Treanor J, et al. Psychosocial factors and the response to influenza vaccination in older adults. Psychosom Med. 2004;66:950-953.
- Cohen S, Tyrrell DA, Smith AP. Psychological stress and susceptibility to the common cold. The New England journal of medicine 1991;325:606-12
- Vedhara K, Bennett PD, Clark S. Enhancement of antibody responses to influenza vaccination in the elderly following a cognitive-behavioural stress management intervention. Psychother Psychosom. 2003;72:245-2
- Santos M. Immunological effects of low-fat diets with and without weight loss. J Am Coll Nutr. 20 03 Apr;22(2):174-82.
- Beck MA. Dietary oxidative stress and the potentiation of viral infection. Annu Rev Nutr. 1998;18:93-116.
- Cunningham–Rundles S, McNeeley DF, Moon A. Mechanisms of nutrient modulation of the immune response. J Allergy Clin Immunol. 2005;115:1119–1128.
- Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Griffiths CJ, Janssens W, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S Jr, Stelmach I, Kumar GT, Urashima M, Camargo CA Jr. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017 Feb 15;356:i6583.
- Naithani R, Huma LC, Holland LE, et al. Antiviral activity of phytochemicals: a comprehensive review. Mini Rev Med Chem 2008;8:1106-1133.
- Kohut ML, Cooper MM, Nickolaus MS, Russell DR, Cunnick JE. Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals. J Gerontol A Biol Sci Med Sci. 2002 Sep;57(9):M557-62.
- Kohut ML, Arntson BA, Lee W, Rozeboom K, Yoon KJ, Cunnick JE, McElhaney J. Moderate exercise improves antibody response to influenza immunization in older adults.Vaccine. 2004 Jun 2;22(17-18):2298-306. Erratum in: Vaccine. 2004 Nov 25;23(2):278.
- de Araújo AL, Silva LC, Fernandes JR, Matias Mde S, Boas LS, Machado CM, Garcez-Leme LE, Benard G. Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine. Age (Dordr). 2015 Dec;37(6):105. doi: 10.1007/s11357-015-9843-4. Epub 2015 Oct 19.
- Malter M, Schriever G, Eilber U. Natural killer cells, vitamins, and other blood components of vegetarian and omnivorous men. Nutr Cancer. 1989;12(3):271-8.
- Douglas RM, Muirhead TC. Fruit, vegetables and acute respiratory infections. Med J Aust. 1983 May 28;1(11):502-3. No abstract available.
- Watzl B, Bub A, Brandstetter BR, Rechkemmer G. Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables. Br J Nutr. 1999 Nov;82(5):383-9.
- Gibson A, Edgar JD, Neville CE, Gilchrist SE, McKinley MC, Patterson CC, Young IS, Woodside JV. Effect of fruit and vegetable consumption on immune function in older people: a randomized controlled trial. Am J Clin Nutr. 2012 Dec;96(6):1429-36. doi: 10.3945/ajcn.112.039057. Epub 2012 Nov 7.
- Li L, Werler MM. Fruit and vegetable intake and risk of upper respiratory tract infection in pregnant women. Public Health Nutr. 2010 Feb;13(2):276-82.
- Charland KM, Buckeridge DL, Hoen AG, Berry JG, Elixhauser A, Melton F, Brownstein JS. Relationship between community prevalence of obesity and associated behavioral factors and community rates of influenza-related hospitalizations in the United States. Influenza Other Respir Viruses. 2013 Sep;7(5):718-28.
- Averill HM, Averill JE. The effect of daily apple consumption on dental caries experience, oral hygiene status and upper respiratory infections. N Y State Dent J. 1968 Aug-Sep;34(7):403-9.
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